21世纪末，人类的科技水平已高度发达，克隆人技术和宇宙航行早已实现，不再是梦想。与此同时，许多科学家仍孜孜不倦追索着人类起源的秘密与真相。通过对许多古老文明的考察与对比，科学家伊丽莎白·肖（Noomi Rapace 饰）和查理·赫洛维（Logan Marshall-Green 饰）发现，人类可能是来自一个遥远星系的外星人创造的。在Weyland公司资助下，他们乘坐维克丝（查理兹·塞隆 Charlize Theron 饰）所掌管的宇宙飞船普罗米修斯号前往那颗未知的星球。 　　经过对当地的考察，地球人的设想成功得到印证。可是他们贸然探查“神的秘密”的行为，也将自己引入万劫不复的深渊……This film is set in 2093 and takes place in the same universe as the 'Alien' movies. A group of explorers, including some archaeologists, are on an "undisclosed" mission. They arrive at a moon trillions of miles away from Earth. The team spot what they believe to be signs of civilization. They go to investigate and find more than just signs, they find conclusive evidence. But some of them have an ulterior motive for being there, including the Weyland Corporation. They believe that this is where the human race actually came from. Things soon turn from excitement to survival once inside their discovery.