对于奥布莉（爱波·塔布琳 Amber Tamblyn 饰）来说，姐姐凯伦（莎拉·米歇尔·盖拉 Sarah Michelle Gellar 饰）的死充满了疑点。两年前，凯伦远赴日本求学，不久之后奥布莉一家就收到了凯伦被关入精神病院的噩耗，而现在，曾经善良美丽的姐姐已经变成了一具冰冷的尸体。奥布莉坚信其中必有古怪，因此，她和专门报道灵异事件的记者伊森（陈冠希 饰）联手，对老房子中的咒怨展开了调查。 　　同一时间，在世界各地，发生了数件离奇死亡事件，而死者与咒怨均有着千丝万缕的关联。咒怨果真这样无孔不入吗？究竟又是谁在背后操纵着这股强大的力量呢？In Pasadena, Mrs. Davis sends her daughter Aubrey Davis to Tokyo to bring her sister Karen Davis, who is interned in a hospital after surviving a fire, back to the USA. After their meeting, Karen dies and Aubrey decides to investigate what happened to her and gets herself trapped in the same situation, being chased by the ghost of the house. Meanwhile in Tokyo, the three high school mates Allison, Vanessa and Miyuki visit the famous haunted house and are also chased by the ghost. In Chicago, Trish moves to the apartment of her boyfriend Bill, who lives with his children, the teenager Lacey and boy Jake. On the next door, weird things happen with their neighbor.