故事讲述以色列情报及特殊使命局（Mossad）一名女特务，乔装潜入伊朗首都德黑兰（Tehran）为进行一项危险任务的惊险过程。Tehran is the story of Tamar Rabinyan, a Mossad computer hacker-agent undertaking her very first mission in the heart of a hostile and menacing city, which also happens to be the place of her birth. Tasked with disabling an Iranian nuclear reactor, her mission has implications not just for the Middle East, but for the entire world order. When the Mossad mission fails, Tamar goes rogue in Tehran as she rediscovers her Iranian roots and becomes romantically entwined with a pro-democracy activist. Tamar's soul-searching leads her to become even more conflicted about her mission, while the tension mounts as Iranian authorities tighten the net in their desperate search to locate her and her Mossad colleagues.