本片改编自推理小说家知念实希人的同名小说，背景设定在被铁栅栏封闭的原精神科医院，讲述在监狱里发生了监禁64名身份不明的住院患者和职员的事件，被牵连的速水(坂口饰)在医院内接连遇到不可思议的事情，并试图逃出的故事。
Shugo Hayami is a doctor at a nursing hospital, which was once a psychiatric hospital. One evening, when Shugo is on night duty, a man in pierrot mask breaks into the hospital and he is not alone. He is with Hitomi Kawasaki, a university student who has been shot by the masked man. The masked man tells Shugo to treat Hitomi. He also takes hostage the 64 people in the hospital. Soon, Shugo and Hitomi try to escape from the hospital and they encounter mysterious cases one at a time.
看开头小丑进医院就知道后面剧情了！。我们来看电影无外乎就是为看永野和坂口。大伙分数可以给高点，也不看看谁当女主（内含少量剧透）。假面病房：单纯的复仇和繁琐的实施计划，让电影充满了矛盾点。假面病房。原来平凡无奇的拥有，到现在竟像是无助的奢求。
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