女叠码仔梅晓鸥（白百何饰）历尽沧桑，在妈阁（澳门）这座赌城中与来历迥异的赌徒打交道，有地产商段凯文（吴刚饰）、有艺术家史奇澜（黄觉饰），也有来自不同阶级的政商人员，连早已堕落低谷的前夫卢晋桐（耿乐饰）都重新卷入她的人生。这些人入赌场就搏杀，出赌场就赖账，女叠码仔过的就是放债和讨债的生活。 　　赌博让人迷失本性，叠码仔与赌徒周旋，也等于与魔鬼打交道，一时假仁假义，一时恩断情绝，赌至终局，谁能寻回本性，谁能鸿运当头？Macau's return to Chinese sovereignty in 1999 ushered in that city's "golden age." By 2012, the value of Macau's gaming industry was nine times that of Las Vegas, and Macao had become the world's foremost gambling destination. During this period, a unique profession arose: "casino brokers," who provided Macao's gamblers with high-interest lines of credit, under-the-table bets, and other services. It was a high-stakes, high-reward business that made for more thrilling play, but amplified the risks for players, brokers and casinos alike. This heightened risk made gambling more exciting and more dangerous for the participants; it also impacted their interpersonal relationships and outlook on life. It was as if everyone involved were walking on a tightrope. By 2014, however, China's ongoing anti-corruption campaign had dealt a serious blow to the gaming industry in Macao, ending the golden age. This is the background against which our story takes place.